Development of speech and articulation and their disruption due to genetic modification and neurological injury.
1 : Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health
* : Corresponding author
30 Guilford Street
London WC1N 1EH -
United Kingdom
The identification of the first gene involved in a speech-language disorder was made possible through the study of a British multi-generational family (the "KE family") in whom half the members have an inherited speech-language disorder caused by a FOXP2 mutation. I will review neuroimaging investigations in the affected members of the KE family which have revealed structural and functional abnormalities in a wide cortical-subcortical network. Functional imaging studies have confirmed dysfunction of this network by revealing abnormal activation in several areas including Broca's area and the putamen during language-related tasks, such as word repetition and generation. In the second part of my talk I will review evidence on the normal development of functional and structural maturation of neural systems underlying speech production and will show examples how acute neurological injury can disrupt these processes.
| Subject : | : | Symposium |
| Topics | : | SY: Advances in Developmental Cognitive Neuroscience |
| PDF version | : |  PDF version |
