Novelty-processing in infants with acyanotic congenital heart defects: a behavioural and ERP study
1 : Cognition and Brain Sciences Unit
(MRC CBU)
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Website
Medical Research Council
15 Chaucer Road, Cambridge, CB2 7EF, England -
United Kingdom
2 : Child Psychology Service, Southampton City Primary Care Trust
3 : Division of Clinical Neurosciences, School of Medicine, University of Southampton
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Website
4 : Department of Paediatric Cardiology, Southampton University Hospitals NHS Trust
5 : Wellcome Trust Clinical Research Facility, Southampton University Hospitals NHS Trust
6 : Division of Clinical Neurosciences, School of Medicine, University of Southampton
7 : Neurosciences Unit, UCL Institute of Child Health
(ICH)
8 : Developmental Cognitive Neuroscience Unit, UCL Institute of Child Health
(ICH)
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Website
niversity College London - Gower Street - London - WC1E 6BT -
United Kingdom
9 : Barts and The London, NHS Trust / Queen Mary University of London
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Website
Barts and The London School of Medicine and Dentistry, Turner Street, London E1 2AD, UK -
United Kingdom
10 : University College London Hospital, NHS Trust
(UCLH)
* : Corresponding author
University College Hospital 235 Euston Road London NW1 2BU -
United Kingdom
Children with congenital heart defects exhibit subtle cognitive deficits in mid-childhood, particularly in the domain of attention. Whether analogous deficits could be observed in infancy is currently unknown. We investigated the allocation of attention to novel stimuli in 12 infants with acyanotic congenital heart defects (Acyanotic-CHD), as this is thought to underpin cognitive development, and may explain the deficits seen in later childhood. Infants with Acyanotic-CHD (n=12) and matched controls (n=12) aged between 6 and 9 months, participated in a behavioural task (novel object exploration), and an event-related potential (ERP) auditory novelty oddball paradigm. Children were also assessed using the Bayley Infant Neurodevelopmental Screener (BINS). Infants with Acyanotic-CHD exhibited decreased exploration of novel objects (P=.044), and altered ERP (negative component) activity, particularly over the centro-parietal cortex (P=.018). However, no significant differences in BINS scores were observed. These findings suggest a mechanism for the cognitive profile of older children.
| Subject : | : | Oral |
| Topics | : | OR: Cognitive and Affective Disorders |
| PDF version | : |  PDF version |
